Senior Scientist - Immune Therapies

Job Description

Senior Scientist – Immune Therapies

Cambridge

Permanent

Competitive depending on skills, background and experience

Working for a growing organisation focused in the area of cell analysis, this is an interesting opportunity to add value and support the progression of unique Platform-based therapeutic approaches.

You will work within the Biology team, and act as the subject matter expert within Immune Therapies. Your core focus will be in the application of your immune cell expertise enabling transfer of cell assays from plate-based formats to a droplet environment, thus facilitating functional readouts and assay combinations.

Role profile:

• You will be responsible for assay optimisation and design of novel workflow at single cell and picolitre level.

• Establishment of reference bench assays and adapt them for use on the microfluidic Platform.

• Working closely with other Scientists and Engineers in a multidisciplinary environment to optimise protocols for genetic and genomic analysis of downstream assays, feeding back your findings to development scientists to inform progression of the on-chip controls.

• Developing and adapting immune cell screening workflows.

• Verification and validation studies in collaboration with the Quality team.

• Creation of SOPs and experimental plans, suggesting ways to improve processes and flagging non-conformance.

• Prepare presentations and keeping abreast of developments in the space to share with the wider team.

Your background:

• PhD in a field related to Immunology, Cell Therapy, CAR Therapies (or similar) plus a minimum of 2 years of Postdoc bench-based experience in either industry or academia OR a Masters along with 5+ years of relevant experience

• Demonstrable experience in optimisation of functional immune cell assays (co-cultures killing/cytotox, cytokine release, activations, differentiation, exhaustion, proliferation)

• Highly capable command of culturing primary immune cells

• Demonstrable experience with genetic modification of immune effector cells (CAR T, lentiviral, CRISPR)

• Good appreciation of TCR discovery workflows or gene editing screening with primary cells (T/NK)

• Astute user of fluorescence-based tools such as fluorescence microscopy or multi-colour flow cytometry

• It would be an advantage to have a good working knowledge gene editing technologies such as CRISPR and base editing

• Working knowledge of TCRSeq and RNASeq, signalling and metabolism

• Excels in a multidisciplinary environment, able to take a broad overview, act with precision and an exceptional problem-solver

If the above sounds like your next role, please apply here or contract bec.johnston@srgtalent.com / 01223 978502 for more information.

]]>