Senior Scientist, Antibody Engineering

Job DescriptionJob Description

Location: Redwood City 
 
Company Overview: 
 
ImmunEdge is a biopharmaceutical company committed to developing novel therapeutics for patients with serious or life-threatening diseases. With a highly experienced team of experts in immunology and drug development, we are pioneering innovative approaches to target and modulate key molecular pathways that regulate the immune response. 
 
At ImmunEdge, we are driven by a shared commitment to improving human health through innovative science. We are building a culture based on collaboration and a deep passion for advancing science. As an early joiner to the company, you will help build and cultivate an environment where every team member is encouraged to challenge ideas, think critically, and contribute their unique perspectives. We value openness, transparency, and continuous learning, and want to empower our employees to take ownership of their work while fostering a sense of community and teamwork.  
 
Join us in shaping the future of biotechnology. Together, we can change lives. 
 
Position: 

 We are seeking a highly motivated and creative Scientist or Senior Scientist to join our Biotherapeutics team. This is a hands-on, lab-based position ideal for a candidate who thrives on leading from the bench—bringing deep technical expertise and scientific curiosity to the design, optimization, and characterization of novel antibody and protein-based therapeutics, including bispecific and multispecific formats, with an emphasis on therapeutic lead optimization. You will play a key role in advancing biologics from early discovery through lead nomination by integrating protein engineering, biophysical analysis, and functional screening.  

Key Responsibilities: 

• Design and engineer antibody-based therapeutics, including bispecifics, antibody fragments, and Fc variants. 

• Apply structure- and sequence-based approaches to optimize affinity, specificity, developability, and stability. 

• Lead antibody optimization efforts to improve potency, manufacturability, and in vivo performance. 

• Develop and execute biologics characterization workflows. 

• Collaborate cross-functionally with your research and development colleagues to advance programs. 

• Contribute to platform innovation and antibody format exploration. 

• Present findings to internal stakeholders and contribute to IND-enabling documentation. 

• Maintain meticulous records and contribute to patent filings and publications.
   

Qualifications: 

• Ph.D. in relevant discipline with at least 3 years of post-grad experience in antibody discovery and engineering, ideally in industry setting  

• Demonstrated expertise in antibody engineering and protein design 

• Proven track record in advancing biologics through lead optimization and/or IND nomination 

• Experience with bispecific antibodies and format screening 

• Proficient in screening molecular interactions, such as by ELISA, flow, and/or BLI/SPR 

• Knowledgeable in antibody sequence and structure to guide molecular evolution  

• Hands-on experience with mammalian expression systems, protein purification, and biophysical assays 

• Familiarity with AI/ML-assisted protein engineering workflows is a plus. 

• Excellent communication skills, attention to details and ability to thrive in a fast-paced, collaborative environment. 

 
Expected Salary Range: $142,000 - $158,000 
 
We encourage candidates of all levels to apply as there at times is  flexibility on job level and responsibilities. Compensation will be based on a variety of factors, including experience, qualifications, internal equity, and location. 
 
ImmunEdge offers a competitive employment package that includes an annual bonus plan, equity, and a generous benefits package including comprehensive health (medical, dental, and vision) insurance for our employees and their families, a 401k plan, FSA plans (medical, dependent), an Employee Assistance Plan, and a holiday and paid time off plan. 
 
At ImmunEdge, we believe that a diverse, open, and inclusive environment and culture is key to our success. We will not be influenced in recruiting, hiring, promoting or any other employment practices by , , citizenship status, , ancestry, , , /expression, , , physical or mental , medical or genetic condition, marital status, veteran status, or any other characteristics protected under applicable federal, state and local laws. ImmunEdge will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable laws. 

Note to External Recruiters: Submission of unsolicited resumes prior to an agreement set in place does not create any implied obligation.  

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