Senior LCMS Scientist

Senior Scientist – Subject Matter Expert (SME) in Mass Spectrometry



Up to £45,000 + Benefits



Full-time, On-site – Southampton



We’re partnering with an innovative scientific organisation to find an experienced Senior Scientist with deep expertise in Mass Spectrometry to join a high-performing team based in Southampton. This role offers the chance to lead analytical strategies, contribute to cutting-edge projects, and support the development of high-quality modified nucleic acid in a fast-paced, collaborative environment.



About the Role



As the subject matter expert in mass spectrometry, you’ll play a central role in driving analytical method development, ensuring high standards in nucleic acid production, and mentoring junior team members. This is a hands-on role in a modern laboratory, where scientific excellence and operational efficiency go hand-in-hand.



Key Responsibilities



Lead and manage analytical workflows using LC-MS, UPLC-MS, HPLC, PAGE, and flash chromatography



Act as the go-to expert for mass spectrometry, including troubleshooting and continuous improvement



Collaborate with cross-functional teams to support small molecule preparation and oligonucleotide synthesis



Maintain, calibrate, and optimise analytical instrumentation in line with internal and ISO quality standards



Support and mentor Associate Scientists and Lab Technicians, providing technical guidance and training



Ensure high levels of documentation accuracy and data integrity



Uphold Health, Safety and Environmental (HSE) standards and promote a safety-first culture



Manage the inventory of analytical reagents and consumables



Stay informed on emerging techniques in nucleic acid chemistry and analytical science



About You



We’re looking for a driven and detail-focused scientist who thrives in a collaborative lab environment and is passionate about pushing the boundaries of analytical science.



You’ll ideally have:



PhD in Chemistry, Analytical Chemistry, or a closely related field



Significant hands-on experience with Mass Spectrometry, ideally including Waters LC-MS systems (Waters Connect experience highly desirable)



Proven track record in high-throughput chemistry or oligonucleotide production environments



Strong grounding in nucleic acid chemistry and experience with purification techniques



Experience working in ISO or GMP-regulated environments



Ability to lead projects and mentor junior staff



Excellent communication, problem-solving and organisational skills



A proactive mindset, able to adapt and perform under pressure



Salary & Benefits



Salary: Up to £45,000 depending on experience



Location: On-site in Southampton



Holidays: 25 days annual leave + 8 bank holidays



Pension: 6% employer contribution



Work-Life Balance: Flexible working hours



Life Assurance: 4x salary



Other Benefits:



Long service awards



Reward and recognition scheme



Employee Assistance Programme with 24/7 remote GP access



Annual flu vaccinations



Cycle to work scheme



Gym discounts



Discount and savings platform



Professional membership reimbursement



Referral incentives



Social events and volunteering days

Want to lead innovation in mass spectrometry and oligonucleotide production?



If you're ready to make an impact in a dynamic and supportive environment, we’d love to hear from you. Apply today or get in touch to learn more