Scientist - NGS

Job Description

About BOSTONGENE:

BostonGene Corporation pioneers biomedical software for advanced patient analysis and personalized therapy decision-making in cancer treatment. Our solution integrates cutting-edge cancer research and clinical data to empower clinicians in tailoring optimal treatment strategies for individual patients.

Position Overview

BostonGene is seeking a bench Scientist to join our R&D next- sequencing (NGS) team in our laboratory located in Waltham, MA. This candidate will support assay development and technical transfer in collaboration with immunology, production, and bioinformatics teams. The candidate will be expected to support NGS protocols, such as RNA and DNA isolation from tissue, cell free DNA isolation from plasma, library preparation, QC, and other lab processes. The role will primarily require laboratory bench work (70-80%) in a BSL-2 laboratory.

Key Responsibilities:

• Perform assay and product development experiments of NGS workflows, including WGS, WES, and liquid biopsy assays for internal and external collaborators
• Troubleshoot and support technical transfer of workflows to the production lab.
• Maintain detailed and accurate records in LIMS, ELN, and in compliance with laboratory protocols and regulatory requirements.
• Assist in the development of laboratory SOPs and batch records.
• Execute and assist with validation studies, bridging studies, and technical reports.
• Stay informed on emerging technologies and trends in NGS to support innovation in assay development.

Qualifications:

• Ph.D. in life sciences or related discipline with 0–3 years of relevant experience,
• OR M.S. with 3–6 years,
• OR B.S. with 6–10 years of hands-on experience.
• (The title will be commensurate with experience.)
• Strong experience in nucleic acid extraction (DNA/RNA) from FFPE, blood, or other clinical samples.
• Proficiency in NGS library prep (short-read and/or long-read), including WGS and WES.
• Excellent problem-solving and troubleshooting skills.
• Strong organizational skills with the ability to manage sample tracking, documentation, and inventory.

Skills & Experience:

• Experience working with liquid biopsy samples (cfDNA/ctDNA, cfRNA, or exosomes).
• Familiarity with NGS QC metrics and analysis tools.
• Understanding of assay validation in regulated environments (GCLP, ISO).
• Demonstrated experience in SOP development and process documentation.
• Strong verbal and written communication skills, with the ability to work effectively in cross-functional teams.
• Proven ability to work in a dynamic, fast-paced environment with shifting priorities.
• Self-motivated and accountable, with a collaborative mindset.

Additional Information

• Ability to stand for prolonged periods and perform repetitive tasks inherent to laboratory work.