Protein Scientist - Phage Display (Scientist/Senior Scientist)

Job Description

Role Summary

In this role you will be a core part of the Protein Science team, working collaboratively with protein scientists to develop soluble high affinity bispecific TCR molecules suitable for later stage clinical development.

Key Deliverables

• Affinity enhance and produce soluble TCR-based therapeutics for clinical development using cutting-edge molecular biology techniques.
• Work collaboratively with the Cell Biology and Engineering teams to guide optimisation and development of soluble TCRs.
• Effectively design and conduct experimental work to align with Company priorities and meet scientific timelines, report results succinctly and effectively.
• Presenting work to your department, project team and the company leadership team

Experience/Qualifications

• A PhD in a relevant biological subject with relevant experience
• (Required) Experience with affinity maturation of TCRs or antibodies using phage display
• (Required) Experienced with a broad range of molecular biology techniques including the design and modification of expression vectors and a range of cloning strategies and techniques
• (Desired) Experience in the design and optimisation of purification protocols to produce high quality proteins and in biochemical analyses of protein properties
• (Desired) Experienced in mammalian expression of proteins (CHO, HEK293 cells)
• (Desired) Experience in developing and executing protein expression, and purification using various FPLC based techniques
• (Desired) Experience in analyses of protein properties using SPR and BLI or other protein binding assay techniques
• (Desired) Direct hands-on laboratory experience in developing high affinity antibodies or soluble TCR molecules
• (Required) Strong organisation and multitasking skills
• Inclusive, collaborative, and thrives in a team environment with a flexible approach to working.
• Strong communication skills with the confidence to challenge appropriately.
• Demonstrable problem-solving ability and creative thinker