Director, Chemical Development

Overview

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Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calicos highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Position Summary

Calico is seeking an experienced and strategic Director of Chemical Development to lead and oversee all aspects of process chemistry and manufacturing for our mid- to late-stage small molecule programs. This role is critical to advancing our pipeline toward commercialization and requires deep technical expertise, leadership, and cross-functional collaboration.

Key Responsibilities

Lead chemical development strategy for small molecule programs from Phase 2 through commercialization, ensuring robust, scalable, and cost-effective processes

Provide technical leadership in route selection, process optimization, impurity control, and analytical support in collaboration with internal teams and external partners

Manage CMC timelines, budgets, and deliverables in alignment with program goals and regulatory requirements

Oversee technology transfer and scale-up activities at CDMOs, ensuring successful cGMP manufacturing for clinical and commercial supply

Author and review CMC sections of global regulatory submissions and support regulatory interactions and inspections

Serve as the technical point of contact with external CMOs and drive performance, quality, and compliance

Collaborate cross-functionally with Quality, Regulatory, Supply Chain, and Project Management teams to ensure alignment and execution

Position Requirements

Ph.D. in Organic Chemistry

Minimum 15 years of experience in process chemistry, with a strong focus on mid to late-stage small molecule development

Demonstrated experience in route design, process scale-up, and cGMP manufacturing

Proven track record in supporting regulatory submissions and health authority interactions

Solid background in Quality by Design, modern process analytical technology, risk management, and process validation

Understanding of current regulatory guidances

Expertise with solid-state chemistry, crystallization, and particle engineering

Experience managing CDMOs and CROs with a focus on quality, cost, and delivery

Strong problem-solving, project management, and communication skills

Ability to lead cross-functional teams and mentor junior staff

Must be willing to work onsite at least 4 days a week

The estimated base salary range for this role is $238,000 - $250,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.

Additional Details

Seniority level: Director

Employment type: Full-time

Job function: Other

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